Pillunat L, Stodtmeister R
University Eye Clinic, Ulm, Federal Republic of Germany.
J Ocul Pharmacol. 1988 Fall;4(3):231-42. doi: 10.1089/jop.1988.4.231.
In an attempt to elucidate whether antiglaucomatous drugs, especially beta-blockers, affect systemic and/or ocular blood flow, we measured ocular perfusion pressures (PP), systemic blood pressure (BP) and heart rate in 50 healthy subjects before and after topical instillation of the following eye drops: timolol 0.5% (n = 10), betaxolol 0.5% (n = 10), carteolol 2% (n = 10), pilocarpine 2% (n = 10) and acetazolamide 750 mg per os (n = 10). The ocular perfusion pressures were measured by OODG as described by Ulrich. By means of this method--retinal and ciliary perfusion pressure can be recorded separately and simultaneously. Our results indicated that, in spite of a statistically significant decrease in IOP in all 5 groups, there was no change in retinal or ciliary perfusion pressure, heart rate or blood pressure in any of the groups except the carteolol subjects. The ocular perfusion pressures should be increased with reduction of the IOP when the systemic parameters remain unchanged. This was not the case in our experiments and therefore it can be suggested that a relative reduction in ocular perfusion pressure occurs with all agents and, in this respect, timolol and betaxolol did not affect ocular perfusion pressure more than pilocarpine and acetazolamide. Carteolol, however, produced a slight decrease (alpha less than 0.02) in ocular perfusion pressure, in spite of lowering of the IOP.
为了阐明抗青光眼药物，尤其是β受体阻滞剂，是否会影响全身和/或眼部血流，我们在50名健康受试者局部滴入以下眼药水前后，测量了眼灌注压（PP）、全身血压（BP）和心率：0.5%噻吗洛尔（n = 10）、0.5%倍他洛尔（n = 10）、2%卡替洛尔（n = 10）、2%毛果芸香碱（n = 10）以及口服750 mg乙酰唑胺（n = 10）。眼灌注压采用乌尔里希描述的OODG方法测量。通过这种方法，可以分别同时记录视网膜和睫状灌注压。我们的结果表明，尽管所有5组的眼压均有统计学意义的下降，但除卡替洛尔组外，其他组的视网膜或睫状灌注压、心率或血压均无变化。当全身参数保持不变时，眼压降低时眼灌注压应升高。但我们的实验并非如此，因此可以认为所有药物都会使眼灌注压相对降低，在这方面，噻吗洛尔和倍他洛尔对眼灌注压的影响并不比毛果芸香碱和乙酰唑胺更大。然而，尽管眼压降低，卡替洛尔仍使眼灌注压略有下降（α<0.02）。
