Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Department of Cardiology and Angiology, Medical School Hannover, Hannover, Germany.
Eur J Heart Fail. 2018 Jan;20(1):16-37. doi: 10.1002/ejhf.1029. Epub 2017 Oct 16.
There is an unmet need for effective treatment strategies to reduce morbidity and mortality in patients with heart failure with preserved ejection fraction (HFpEF). Until recently, attention in patients with HFpEF was almost exclusively focused on the left side. However, it is now increasingly recognized that right heart dysfunction is common and contributes importantly to poor prognosis in HFpEF. More insights into the development of right heart dysfunction in HFpEF may aid to our knowledge about this complex disease and may eventually lead to better treatments to improve outcomes in these patients. In this position paper from the Heart Failure Association of the European Society of Cardiology, the Committee on Heart Failure with Preserved Ejection Fraction reviews the prevalence, diagnosis, and pathophysiology of right heart dysfunction and failure in patients with HFpEF. Finally, potential treatment strategies, important knowledge gaps and future directions regarding the right side in HFpEF are discussed.
对于心力衰竭伴射血分数保留（HFpEF）患者，存在减轻发病率和死亡率的有效治疗策略的需求。直到最近，HFpEF 患者的关注几乎完全集中在左侧。然而，现在越来越认识到，右心功能障碍很常见，对 HFpEF 的预后有重要影响。对 HFpEF 中右心功能障碍发展的更多了解可能有助于我们了解这种复杂疾病，并最终导致更好的治疗方法，以改善这些患者的结局。在欧洲心脏病学会心力衰竭协会的这份立场文件中，射血分数保留心力衰竭委员会审查了 HFpEF 患者右心功能障碍和衰竭的患病率、诊断和病理生理学。最后，讨论了 HFpEF 中右侧的潜在治疗策略、重要的知识空白和未来方向。
