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基于 FLUKA 的扫描质子治疗中次级中子剂量的蒙特卡罗模拟。

Monte Carlo simulation of secondary neutron dose for scanning proton therapy using FLUKA.

机构信息

Department of Radiological Science, Yonsei University, Wonju, Korea.

Program in Biomedical Radiation Sciences, Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of Korea.

出版信息

PLoS One. 2017 Oct 18;12(10):e0186544. doi: 10.1371/journal.pone.0186544. eCollection 2017.

DOI:10.1371/journal.pone.0186544
PMID:29045491
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5646843/
Abstract

Proton therapy is a rapidly progressing field for cancer treatment. Globally, many proton therapy facilities are being commissioned or under construction. Secondary neutrons are an important issue during the commissioning process of a proton therapy facility. The purpose of this study is to model and validate scanning nozzles of proton therapy at Samsung Medical Center (SMC) by Monte Carlo simulation for beam commissioning. After the commissioning, a secondary neutron ambient dose from proton scanning nozzle (Gantry 1) was simulated and measured. This simulation was performed to evaluate beam properties such as percent depth dose curve, Bragg peak, and distal fall-off, so that they could be verified with measured data. Using the validated beam nozzle, the secondary neutron ambient dose was simulated and then compared with the measured ambient dose from Gantry 1. We calculated secondary neutron dose at several different points. We demonstrated the validity modeling a proton scanning nozzle system to evaluate various parameters using FLUKA. The measured secondary neutron ambient dose showed a similar tendency with the simulation result. This work will increase the knowledge necessary for the development of radiation safety technology in medical particle accelerators.

摘要

质子治疗是癌症治疗中一个快速发展的领域。在全球范围内，许多质子治疗设施正在投入使用或正在建设中。在质子治疗设施的调试过程中，次级中子是一个重要问题。本研究的目的是通过蒙特卡罗模拟为束流调试对三星医疗中心（SMC）的质子治疗扫描喷嘴进行建模和验证。调试后，模拟并测量了质子扫描喷嘴（龙门架 1）的次级中子环境剂量。进行此模拟是为了评估束流特性，如百分深度剂量曲线、布拉格峰和远端下降，以便与测量数据进行验证。使用经过验证的射束喷嘴，模拟了二次中子环境剂量，然后将其与来自龙门架 1 的测量环境剂量进行比较。我们在几个不同的点计算了二次中子剂量。我们使用 FLUKA 证明了对质子扫描喷嘴系统进行建模以评估各种参数的有效性。测量的次级中子环境剂量与模拟结果具有相似的趋势。这项工作将为医疗粒子加速器辐射安全技术的发展提供必要的知识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/299b/5646843/bc5cec7c4979/pone.0186544.g013.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/299b/5646843/2ec6689a0b82/pone.0186544.g009.jpg
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