一个克隆的八聚体转录因子可刺激非B细胞中淋巴特异性启动子的转录。
A cloned octamer transcription factor stimulates transcription from lymphoid-specific promoters in non-B cells.
作者信息
Müller M M, Ruppert S, Schaffner W, Matthias P
机构信息
Institut für Molekularbiologie II der Universität Zürich, Switzerland.
出版信息
Nature. 1988 Dec 8;336(6199):544-51. doi: 10.1038/336544a0.
DOI:10.1038/336544a0
PMID:2904653
Abstract
The complementary DNA coding for a lymphocyte-specific transcription factor binding to the DNA 'octamer' sequence TNATTTGCAT has been cloned. The nucleotide sequence shows homology to the homoeobox domain. Expression of this cDNA in HeLa cells is sufficient for a strong transcriptional activation of B-cell-specific promoters.
摘要
编码与DNA“八聚体”序列TNATTTGCAT结合的淋巴细胞特异性转录因子的互补DNA已被克隆。核苷酸序列显示与同源异型框结构域具有同源性。该cDNA在HeLa细胞中的表达足以强烈激活B细胞特异性启动子的转录。
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