将人类神经干细胞移植到阿尔茨海默病小鼠的胼胝体中。
Human neural stem cell transplantation into the corpus callosum of Alzheimer's mice.
作者信息
McGinley Lisa M, Kashlan Osama N, Chen Kevin S, Bruno Elizabeth S, Hayes John M, Backus Carey, Feldman Seth, Kashlan Bader N, Johe Karl, Feldman Eva L
机构信息
Department of Neurology University of Michigan Ann Arbor Michigan.
Department of Neurosurgery University of Michigan Ann Arbor Michigan.
出版信息
Ann Clin Transl Neurol. 2017 Aug 18;4(10):749-755. doi: 10.1002/acn3.443. eCollection 2017 Oct.
Abstract
The hippocampus has been the target of stem cell transplantations in preclinical studies focused on Alzheimer's disease, with results showing improvements in histological and behavioral outcomes. The corpus callosum is another structure that is affected early in Alzheimer's disease. Therefore, we hypothesize that this structure is a novel target for human neural stem cell transplantation in transgenic Alzheimer's disease mouse models. This study demonstrates the feasibility of targeting the corpus callosum and identifies an effective immunosuppression regimen for transplanted neural stem cell survival. These results support further preclinical development of the corpus callosum as a therapeutic target in Alzheimer's disease.
摘要
在针对阿尔茨海默病的临床前研究中，海马体一直是干细胞移植的目标，结果显示组织学和行为学结果有所改善。胼胝体是另一个在阿尔茨海默病早期就会受到影响的结构。因此，我们假设这个结构是转基因阿尔茨海默病小鼠模型中人类神经干细胞移植的一个新靶点。本研究证明了靶向胼胝体的可行性，并确定了一种有效的免疫抑制方案以确保移植神经干细胞的存活。这些结果支持将胼胝体作为阿尔茨海默病治疗靶点进行进一步的临床前开发。
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