实验性缺血性脑卒中大鼠脑内移植间充质干细胞的治疗效果及迁移。
Therapeutic Efficacy and Migration of Mesenchymal Stem Cells after Intracerebral Transplantation in Rats with Experimental Ischemic Stroke.
机构信息
Federal Center of Brain Research and Neurotechnologies, Federal Medical-Biological Agency of Russia, Moscow, Russia.
Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
出版信息
Bull Exp Biol Med. 2023 May;175(1):116-125. doi: 10.1007/s10517-023-05822-1. Epub 2023 Jun 19.
We studied therapeutic efficacy and migration characteristics of mesenchymal stem cells isolated from the human placenta after their intracerebral (stereotactic) administration to rats with the experimental ischemic stroke. It was shown that cell therapy significantly improved animal survival rate and reduced the severity of neurological deficit. New data on the migration pathways of transplanted cells in the brain were obtained.
我们研究了从人胎盘分离的间充质干细胞在脑内（立体定向）给予实验性缺血性卒中大鼠后的治疗效果和迁移特征。结果表明，细胞治疗显著提高了动物的存活率并降低了神经功能缺损的严重程度。获得了关于移植细胞在脑内迁移途径的新数据。
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