Li Kaishu, Zheng Yin, Cai Shubing, Fan Zhiming, Yang Junyi, Liu Yuanrun, Liang Shengqi, Song Meihui, Du Siyuan, Qi Ling
Department of Neurosurgery, The Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan, Guangdong 511518, China.
Institute of Digestive Diseases, The Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan, Guangdong 511518, China.
Genes Dis. 2024 Aug 26;12(3):101398. doi: 10.1016/j.gendis.2024.101398. eCollection 2025 May.
The subventricular zone (SVZ) is a region surrounding the lateral ventricles that contains neural stem cells and neural progenitor cells, which can proliferate and differentiate into various neural and glial cells. SVZ cells play important roles in neurological diseases like neurodegeneration, neural injury, and glioblastoma multiforme. Investigating the anatomy, structure, composition, physiology, disease associations, and related mechanisms of SVZ is significant for neural stem cell therapy and treatment/prevention of neurological disorders. However, challenges remain regarding the mechanisms regulating SVZ cell proliferation, differentiation, and migration, delivering cells to damaged areas, and immune responses. In-depth studies of SVZ functions and related therapeutic developments may provide new insights and approaches for treating brain injuries and degenerative diseases, as well as a scientific basis for neural stem cell therapy. This review summarizes research findings on SVZ and neurological diseases to provide references for relevant therapies.
脑室下区（SVZ）是围绕侧脑室的一个区域，其中含有神经干细胞和神经祖细胞，这些细胞能够增殖并分化为各种神经细胞和神经胶质细胞。SVZ细胞在神经退行性变、神经损伤和多形性胶质母细胞瘤等神经系统疾病中发挥着重要作用。研究SVZ的解剖结构、组成、生理学、疾病关联及相关机制，对于神经干细胞治疗以及神经系统疾病的治疗/预防具有重要意义。然而，在调节SVZ细胞增殖、分化和迁移的机制、将细胞递送至受损区域以及免疫反应等方面仍存在挑战。对SVZ功能及相关治疗进展的深入研究，可能为治疗脑损伤和退行性疾病提供新的见解和方法，并为神经干细胞治疗提供科学依据。本综述总结了关于SVZ和神经系统疾病的研究结果，以为相关治疗提供参考。
