Department of Psychology.
Division of Gastroenterology, Hepatology, & Nutrition, Department of Pediatrics.
J Pediatr Psychol. 2018 Apr 1;43(3):331-341. doi: 10.1093/jpepsy/jsx117.
To determine whether the experience of persistent epigastric pain is associated with sleep disturbances in children with eosinophilic esophagitis (EoE). We hypothesized that children with EoE and persistent epigastric pain would (1) self-report greater current and worst pain severity, and (2) experience more disturbed sleep on objective and subjective measures in comparison with children with EoE but no persistent pain and healthy children.
Fifty children with EoE were recruited for this cross-sectional study, of which 24 (48%) reported experiencing persistent epigastric pain. The remaining 26 (52%) children with EoE denied experiencing persistent pain. An additional 25 healthy children without EoE or persistent pain were included. All children provided severity ratings of current pain and worst pain experienced over the past week. Children then completed 12 consecutive nights of ambulatory sleep monitoring via actigraphy in the home. Caregivers provided information regarding their child's sleep patterns and internalizing symptoms.
Children with EoE and persistent pain reported significantly greater severity of current pain (p < .001) and worst pain over the past week (p < .001) compared with EoE without persistent pain and healthy children. Compared with the other groups, children with EoE and persistent pain also demonstrated greater actigraphic sleep disturbances, lower sleep efficiency (p = .004) and greater wake after sleep onset (p = .034).
This study provides novel evidence that a significant proportion of children with EoE experience persistent symptoms of epigastric pain. Persistent pain was associated with significant sleep disturbances in children with EoE.
确定持续性上腹痛体验是否与嗜酸性食管炎（EoE）患儿的睡眠障碍有关。我们假设，与没有持续性疼痛的 EoE 患儿和健康儿童相比，患有 EoE 且持续性上腹痛的儿童（1）会自我报告更高的当前和最严重疼痛程度，以及（2）在客观和主观测量上经历更多的睡眠障碍。
本横断面研究纳入了 50 名 EoE 患儿，其中 24 名（48%）报告有持续性上腹痛。其余 26 名（52%）EoE 患儿否认有持续性疼痛。还纳入了 25 名没有 EoE 或持续性疼痛的健康儿童。所有儿童均提供了过去一周内当前疼痛和最严重疼痛的严重程度评分。然后，儿童在家中通过活动记录仪连续 12 晚进行动态睡眠监测。照顾者提供了有关其子女睡眠模式和内化症状的信息。
患有 EoE 和持续性疼痛的儿童报告的当前疼痛和过去一周内最严重疼痛的严重程度显著高于没有持续性疼痛的 EoE 儿童和健康儿童（p<0.001）。与其他两组相比，患有 EoE 和持续性疼痛的儿童还表现出更明显的活动记录仪睡眠障碍，更低的睡眠效率（p=0.004）和更大的睡眠后觉醒时间（p=0.034）。
这项研究提供了新的证据，表明相当一部分 EoE 患儿经历持续性上腹痛症状。持续性疼痛与 EoE 患儿的睡眠障碍显著相关。
