患有镰状细胞病的学龄前儿童听觉注意力的神经生理处理改变。
Altered Neurophysiological Processing of Auditory Attention in Preschool Children With Sickle Cell Disease.
机构信息
School of Psychology, University College Dublin.
Developmental Neurosciences, UCL Great Ormond Street Institute of Child Health.
出版信息
J Pediatr Psychol. 2018 Sep 1;43(8):856-869. doi: 10.1093/jpepsy/jsx115.
OBJECTIVE
Sickle cell disease (SCD) is a genetic red blood cell disorder that often leads to stroke and executive dysfunction in school-age children and adults. This study aimed to characterize the development of the neural correlates of selective attention, an early component of executive function, in preschool children with SCD.
METHODS
Auditory event-related potentials (ERPs) were recorded while children attended to a story stream in one ear and ignored a second story in the other ear interchangeably. In total, 12 patients (mean age = 5.5, 7 males) and 22 typically developing children (mean age = 4.4, 10 males) were included in the final analyses.
RESULTS
By 100 ms, more positive ERP amplitudes were observed for attended relative to unattended stimuli in typically developing children but not those with SCD, suggesting deficits in the ability to focus attention. Reduced attention effects were associated with lower performance intellectual quotient.
CONCLUSION
There are deficits in early attention modulation in young children with SCD.
目的
镰状细胞病（SCD）是一种遗传性红细胞疾病，常导致学龄儿童和成人发生中风和执行功能障碍。本研究旨在描述镰状细胞病学龄前儿童选择性注意的神经相关性的发展，选择性注意是执行功能的早期成分。
方法
在儿童交替地用一只耳朵听故事流，用另一只耳朵忽略另一个故事时，记录听觉事件相关电位（ERPs）。最终，共有 12 名患者（平均年龄=5.5 岁，7 名男性）和 22 名典型发育儿童（平均年龄=4.4 岁，10 名男性）纳入最终分析。
结果
在 100ms 时，与未关注的刺激相比，典型发育儿童的 ERP 振幅更正向，表明他们在集中注意力的能力上存在缺陷，但 SCD 儿童则没有。注意力效应的降低与较低的智商表现相关。
结论
患有 SCD 的幼儿存在早期注意力调节缺陷。
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