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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Peral de Bruno M, Lebenshon de Chialvo P, Coviello A

Departamento de Fisiología, INSIBIO, San Miguel de Tucumán, Argentina.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1988;90(1):195-201. doi: 10.1016/0742-8413(88)90119-3.

The vascular response to Asn1-Val5 angiotensin II (A II) in aortic rings from Bufo arenarum toad was studied. 2. Tachyphylaxis in response to A II could be abolished after incubation with norepinephrine (NE). 3. Phentolamine treatment partially inhibited the pressor effects to A II. 4. Sar1-Ile8 A II and Sar1-Ala8 A II significantly attenuated the vascular effects of A II and did not affect the NE response. 5. We conclude that the pressor response to A II has a direct contractile effect and a catecholamine dependent component in aortic rings of Bufo arenarum toad.

研究了中华大蟾蜍主动脉环对天冬酰胺1-缬氨酸5血管紧张素II（A II）的血管反应。2. 与去甲肾上腺素（NE）孵育后，对A II的快速耐受性可被消除。3. 酚妥拉明处理部分抑制了对A II的升压作用。4. 肌氨酸1-异亮氨酸8 A II和肌氨酸1-丙氨酸8 A II显著减弱了A II的血管效应，且不影响NE反应。5. 我们得出结论，在中华大蟾蜍主动脉环中，对A II的升压反应具有直接收缩作用和儿茶酚胺依赖性成分。

Peral de Bruno M, Lebenshon de Chialvo P, Coviello A

Departamento de Fisiología, INSIBIO, San Miguel de Tucumán, Argentina.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1988;90(1):195-201. doi: 10.1016/0742-8413(88)90119-3.

The vascular response to Asn1-Val5 angiotensin II (A II) in aortic rings from Bufo arenarum toad was studied. 2. Tachyphylaxis in response to A II could be abolished after incubation with norepinephrine (NE). 3. Phentolamine treatment partially inhibited the pressor effects to A II. 4. Sar1-Ile8 A II and Sar1-Ala8 A II significantly attenuated the vascular effects of A II and did not affect the NE response. 5. We conclude that the pressor response to A II has a direct contractile effect and a catecholamine dependent component in aortic rings of Bufo arenarum toad.

研究了中华大蟾蜍主动脉环对天冬酰胺1-缬氨酸5血管紧张素II（A II）的血管反应。2. 与去甲肾上腺素（NE）孵育后，对A II的快速耐受性可被消除。3. 酚妥拉明处理部分抑制了对A II的升压作用。4. 肌氨酸1-异亮氨酸8 A II和肌氨酸1-丙氨酸8 A II显著减弱了A II的血管效应，且不影响NE反应。5. 我们得出结论，在中华大蟾蜍主动脉环中，对A II的升压反应具有直接收缩作用和儿茶酚胺依赖性成分。