美洲牛蛙（Rana catesbeiana）血管紧张素I对两栖动物组织的影响。

Effects of angiotensin I of the American bullfrog Rana catesbeiana on amphibian tissues.

Coviello A, Soria M O, Proto M C, Peral de Bruno M, Berman D M, Khosla M C, Bumpus F M

Departamento de Fisiología, INSIBIO, San Miguel de Tucumán, Argentina.

Comp Biochem Physiol Comp Physiol. 1993 Jan;104(1):113-6. doi: 10.1016/0300-9629(93)90017-x.

Abstract

The effect of bullfrog angiotensin I [Asp1, Val5, Asn9] angiotensin I, (AT I) on short-circuit current (SCC) on isolated toad skin and aorta contractility was examined. 2. AT I increased SCC in toad skin, the effect was partially inhibited by angiotensin-converting enzyme inhibitor (ACEI) teprotide. 3. AT I induced contractile responses in isolated rings of toad aorta. This effect was partially inhibited by captopril and completely blocked by the peptide antagonist [Sar1, Ile8] angiotensin II. 4. Present results indicate that this homologue AT I would act in amphibian tissues by conversion to AT II.

摘要

研究了牛蛙血管紧张素I [天冬氨酸1、缬氨酸5、天冬酰胺9]血管紧张素I（AT I）对离体蟾蜍皮肤短路电流（SCC）和主动脉收缩性的影响。2. AT I增加了蟾蜍皮肤的SCC，血管紧张素转换酶抑制剂（ACEI）替普罗肽部分抑制了该作用。3. AT I诱导离体蟾蜍主动脉环产生收缩反应。卡托普利部分抑制了该作用，而肽拮抗剂[Sar1，Ile8]血管紧张素II则完全阻断了该作用。4. 目前的结果表明，这种同源物AT I在两栖动物组织中可能通过转化为AT II起作用。