Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom.
Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
Elife. 2017 Oct 19;6:e28755. doi: 10.7554/eLife.28755.
Systemic vascular pressure in vertebrates is regulated by a range of factors: one key element of control is peripheral resistance in tissue capillary beds. Many aspects of the relationship between central control of vascular flow and peripheral resistance are unclear. An important example of this is the relationship between hypoxic response in individual tissues, and the effect that response has on systemic cardiovascular adaptation to oxygen deprivation. We show here how hypoxic response via the HIF transcription factors in one large vascular bed, that underlying the skin, influences cardiovascular response to hypoxia in mice. We show that the response of the skin to hypoxia feeds back on a wide range of cardiovascular parameters, including heart rate, arterial pressures, and body temperature. These data represent the first demonstration of a dynamic role for oxygen sensing in a peripheral tissue directly modifying cardiovascular response to the challenge of hypoxia.
控制的一个关键因素是组织毛细血管床的外周阻力。中央血管流量控制与外周阻力之间的关系有许多方面尚不清楚。这方面的一个重要例子是单个组织缺氧反应与该反应对全身心血管系统对缺氧适应的影响之间的关系。我们在此展示了通过位于皮肤下的一个大血管床中的 HIF 转录因子进行的缺氧反应如何影响小鼠的缺氧心血管反应。我们表明，皮肤对缺氧的反应会影响广泛的心血管参数，包括心率、动脉压和体温。这些数据首次证明了氧感应在一个外周组织中的动态作用，该作用可直接改变对缺氧挑战的心血管反应。
