Eason C T, Pattison A, Howells D D, Bonner F W
Toxicology Department, Sterling-Winthrop Research Centre, Alnwick, Northumberland, UK.
J Pharm Pharmacol. 1988 Jul;40(7):512-3. doi: 10.1111/j.2042-7158.1988.tb05289.x.
The potential of ciprofibrate to inhibit gastric secretion has been investigated in the rat. A significant gastric antisecretory effect was observed following a single oral administration of 300 and 500 mg kg-1 and following a single intraduodenal dose of 100, 300 and 500 mg kg-1. The toxicological significance of this finding is discussed in the light of a spate of recent publications linking changes in gastric morphology with hypergastrinaemia produced as a secondary effect of inhibition of acid secretion.
已在大鼠中研究了环丙贝特抑制胃酸分泌的潜力。单次口服300和500 mg kg-1以及单次十二指肠内给予100、300和500 mg kg-1后，观察到显著的胃抗分泌作用。鉴于最近一系列将胃形态变化与作为胃酸分泌抑制的继发效应而产生的高胃泌素血症联系起来的出版物，讨论了这一发现的毒理学意义。
