Arnold A, McAuliff M P, Beyler A L
J Pharm Sci. 1979 Dec;68(12):1557-8. doi: 10.1002/jps.2600681227.
Ciprofibrate, a new orally effective hypolipidemic agent like clofibrate, suppressed tyloxapol-induced hypercholesterolemia in rats. Ciprofibrate at 10 mg/kg was effective. Clofibrate required a dosage of 180 mg/kg to suppress the tyloxapol effect. Norepinephrine-induced free fatty acid release was inhibited by clofibrate in rats in accordance with earlier findings. Ciprofibrate and lifibrate differed from clofibrate in that, at hypocholesterolemically effective doses, neither inhibited the hormone sensitive lipase in vivo.
环丙贝特是一种新型口服有效的降血脂药物，与氯贝丁酯类似，可抑制大鼠中吐温诱导的高胆固醇血症。10mg/kg的环丙贝特有效。氯贝丁酯需要180mg/kg的剂量才能抑制吐温的作用。根据早期研究结果，氯贝丁酯可抑制大鼠体内去甲肾上腺素诱导的游离脂肪酸释放。环丙贝特和利贝特与氯贝丁酯不同，在降胆固醇有效剂量下，它们在体内均不抑制激素敏感性脂肪酶。
