Nishihata T, Suzuka T, Yata N, Sakai K
Pharmaceutical Chemistry Department, University of Kansas, Lawrence 66046.
J Pharm Pharmacol. 1988 Jul;40(7):516-8. doi: 10.1111/j.2042-7158.1988.tb05291.x.
The effect of the content of protein thiols and non-protein thiols in the tissue of the rat small intestinal loop on the absorption of cefmetazole has been investigated. 2,4-Dinitrophenol (DNP), at a concentration of 500 microM, caused rapid protein thiol loss, followed by non-protein thiol loss, along with a decrease of cefmetazole absorption by the intestine. The coadministration of 75 mM salicylate with DNP inhibited the effect of DNP on protein thiols and cefmetazole absorption but not on non-protein thiol loss by DNP.
