通过结合共同位点的含同源异型结构域蛋白对转录的激活与抑制
Activation and repression of transcription by homoeodomain-containing proteins that bind a common site.
作者信息
Jaynes J B, O'Farrell P H
机构信息
Department of Biochemistry and Biophysics, University of California, San Francisco 94143.
出版信息
Nature. 1988;336(6201):744-9. doi: 10.1038/336744a0.
Abstract
The product of the fushi tarazu (ftz) gene is shown to be a site-dependent activator of transcription. In vitro-defined binding sites act as ftz-dependent enhancers in cultured cells. Another homoeodomain-containing protein, the engrailed gene product, competes for homoeodomain-binding sites and counteracts ftz activation.
摘要
腹节基因（ftz）的产物被证明是一种依赖于位点的转录激活因子。体外定义的结合位点在培养细胞中作为依赖于ftz的增强子发挥作用。另一种含同源异型结构域的蛋白质，即engrailed基因产物，竞争同源异型结构域结合位点并抵消ftz的激活作用。
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