Yin Zhihua, Cui Zhigang, Ren Yangwu, Xia Lingzi, Li Hang, Zhou Baosen
Department of Epidemiology, School of Public Health, China Medical University, Shenyang 110122, PR China.
Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang 110122, PR China.
Oncotarget. 2017 Aug 10;8(41):70890-70898. doi: 10.18632/oncotarget.20174. eCollection 2017 Sep 19.
The common polymorphism rs11614913 in miR-196a2 might be associated with lung cancer risk for non-smoking females in northeast China.
The genotypes of rs11614913 in miR-196a2 were determined by a case-control study including 1003 patients with lung cancer and 1003 healthy controls. The tissues were detected to assess the miRNA expression. Secondary structures of miR-196a2 were predicted.
There was a significant association between miR-196a2 rs11614913 and lung cancer risk in Chinese non-smoking females. Individuals carrying TC or CC genotype had increased risk of lung cancer compared with TT genotype (adjusted risks were 1.63 and 1.67). The C allele was associated with a higher risk of lung cancer with a significant risk of 1.27. The similar significant results were also found in lung adenocarcinoma. There was a significant association between miR-196a2 expression and lung cancer risk (t=2.594, P=0.012). The relative expression of miR-196a2 was significantly higher for CC genotype comparing with the CT or TT genotype in tumor tissues (P values were all 0.003). The optimal free energies were different for T allele and C allele.
The polymorphism rs11614913 in miR-196a2 may be associated with lung cancer risks in Chinese non-smoking females through affecting miR-196a2 expression and secondary structure.
在中国东北地区，miR-196a2中常见的多态性rs11614913可能与非吸烟女性患肺癌的风险相关。
通过病例对照研究确定了1003例肺癌患者和1003例健康对照者中miR-196a2的rs11614913基因型。检测组织以评估miRNA表达。预测了miR-196a2的二级结构。
在中国非吸烟女性中，miR-196a2 rs11614913与肺癌风险之间存在显著关联。与TT基因型相比，携带TC或CC基因型的个体患肺癌的风险增加（调整后的风险分别为1.63和1.67）。C等位基因与较高的肺癌风险相关，风险显著为1.27。在肺腺癌中也发现了类似的显著结果。miR-196a2表达与肺癌风险之间存在显著关联（t = 2.594，P = 0.012）。在肿瘤组织中，CC基因型的miR-196a2相对表达显著高于CT或TT基因型（P值均为0.003）。T等位基因和C等位基因的最佳自由能不同。
miR-196a2中的多态性rs11614913可能通过影响miR-196a2的表达和二级结构与中国非吸烟女性的肺癌风险相关。
