Temel M T, Coskun M E, Akbayram S, Demiryürek A T
Bratisl Lek Listy. 2017;118(8):491-494. doi: 10.4149/BLL_2017_094.
The aim of this study was to assess the influence of neutrophil to lymphocyte (N/L) ratio and platelet indices on patent ductus arteriosus (PDA) in preterm infants.
PDA is a common problem with potentially serious associated morbidities in preterm neonates.
Premature infants with hemodynamically significant PDA (n = 47) and a control group without PDA (n = 50) who were hospitalized in the neonatal intensive care unit were retrospectively evaluated. The characteristics, perinatal factors, N/L ratio, platelet counts and other platelet indices of the infants in both groups during the first 3 days of life were recorded.
Platelet counts were significantly lower in the patient group than in the control group (p = 0.0343). There was a marked positive correlation between body weight and N/L ratio in preterm infants with PDA (p = 0.0001). PDA was associated with low platelet count.
Our results showed that N/L ratio is positively correllated with body weight in PDA group. These data suggest that platelet counts and N/L ratio might be useful predictors for the early diagnosis and evaluation of the clinical course of PDA in preterm infants (Tab. 2, Ref. 28).
本研究旨在评估中性粒细胞与淋巴细胞比值（N/L比值）及血小板指标对早产儿动脉导管未闭（PDA）的影响。
PDA是早产新生儿中常见的问题，可能伴有严重的相关疾病。
回顾性评估在新生儿重症监护病房住院的有血流动力学意义的PDA早产儿（n = 47）和无PDA的对照组（n = 50）。记录两组婴儿出生后前3天的特征、围产期因素、N/L比值、血小板计数及其他血小板指标。
患者组血小板计数显著低于对照组（p = 0.0343）。有PDA的早产儿体重与N/L比值之间存在显著正相关（p = 0.0001）。PDA与血小板计数低有关。
我们的结果表明，PDA组中N/L比值与体重呈正相关。这些数据表明，血小板计数和N/L比值可能是早产儿PDA早期诊断及临床病程评估的有用预测指标（表2，参考文献28）。
