Oliveira Bruno L, Caravan Peter
Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, UK.
Dalton Trans. 2017 Oct 31;46(42):14488-14508. doi: 10.1039/c7dt02634j.
The development of new methods to image the onset and progression of thrombosis is an unmet need. Non-invasive molecular imaging techniques targeting specific key structures involved in the formation of thrombosis have demonstrated the ability to detect thrombus in different disease state models and in patients. Due to its high concentration in the thrombus and its essential role in thrombus formation, the detection of fibrin is an attractive strategy for identification of thrombosis. Herein we provide an overview of recent and selected fibrin-targeted probes for molecular imaging of thrombosis by magnetic resonance imaging (MRI), positron emission tomography (PET), single photon emission computed tomography (SPECT), and optical techniques. Emphasis is placed on work that our lab has explored over the last 15 years that has resulted in the progression of the fibrin-binding PET probe [Cu]FBP8 from preclinical studies into human trials.
开发用于成像血栓形成起始和进展的新方法是一项尚未满足的需求。针对血栓形成过程中涉及的特定关键结构的非侵入性分子成像技术已证明能够在不同疾病状态模型和患者中检测血栓。由于纤维蛋白在血栓中浓度高且在血栓形成中起关键作用，检测纤维蛋白是识别血栓形成的一种有吸引力的策略。本文我们概述了最近通过磁共振成像（MRI）、正电子发射断层扫描（PET）、单光子发射计算机断层扫描（SPECT）和光学技术用于血栓分子成像的选定纤维蛋白靶向探针。重点介绍了我们实验室在过去15年中所开展的工作，这些工作使得纤维蛋白结合PET探针[Cu]FBP8从临床前研究发展到人体试验。
