非亲电介质中的分子间 Pummerer 偶联与碳亲核试剂。
Intermolecular Pummerer Coupling with Carbon Nucleophiles in Non-Electrophilic Media.
机构信息
Department of Organic Chemistry, Stockholm University, Arrhenius Laboratory, 106 91, Stockholm, Sweden.
Berzelii EXSELENT Center for Porous Materials, Stockholm University, Arrhenius Laboratory, 106 91, Stockholm, Sweden.
出版信息
Angew Chem Int Ed Engl. 2017 Dec 11;56(50):16042-16046. doi: 10.1002/anie.201709715. Epub 2017 Nov 15.
A new Pummerer-type C-C coupling protocol is introduced based on turbo-organomagnesium amides, which unlike traditional Pummerer reactions, does not require strong electrophilic activators, engages a broad range of C(sp )-, C(sp )-, and C(sp)-nucleophiles, and seamlessly integrates with C-H and C-X magnesiation. Given the central character of sulfur compounds in organic chemistry, this protocol allows access to unrelated carbonyls, olefins, organometallics, halides, and boronic esters through a single strategy.
介绍了一种基于涡轮有机镁酰胺的新型 Pummerer 型 C-C 偶联反应协议，与传统的 Pummerer 反应不同，该协议不需要强亲电活化剂，可与广泛的 C(sp )-、C(sp )-和 C(sp )-亲核试剂反应，并与 C-H 和 C-X 镁化无缝集成。鉴于硫化合物在有机化学中的核心地位，该协议允许通过单一策略获得与羰基、烯烃、有机金属、卤化物和硼酸酯无关的化合物。
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