Department of Infectious Diseases and Pulmonary Medicine, Charité Hospital Berlin, Augustenburger Platz 1, 13352 Berlin, Germany.
INSERM U1211, Rare Diseases, Genetics and Metabolism, University of Bordeaux, CHU Pellegrin, École de Sages-Femmes, 33000 Bordeaux, France.
Mitochondrion. 2018 Jul;41:28-36. doi: 10.1016/j.mito.2017.10.008. Epub 2017 Oct 18.
Upon microbial infection, cells of the innate immune system undergo profound metabolic reprogramming in order to eradicate pathogens, promote inflammation, and eventually restore tissue homeostasis. Mitochondria are at the core of these adaptations, given their dual role as metabolic hubs and innate immune signaling platforms. The mitochondrial electron transport chain (ETC) is very well characterized at the genetic, molecular, structural, and biochemical level. In contrast, the role for mitochondrial ETC and metabolites beyond fulfilling cellular ATP synthesis in innate immune cell biology was not understood until recently. Here we discuss the latest advances in our understanding of immune functions of mitochondria and particularly the mitochondrial respiratory chain.
在微生物感染后，先天免疫系统的细胞会经历深刻的代谢重编程，以消灭病原体、促进炎症，最终恢复组织内稳态。线粒体在这些适应中处于核心地位，因为它们具有代谢中心和先天免疫信号平台的双重作用。线粒体电子传递链 (ETC) 在遗传、分子、结构和生化水平上都得到了很好的描述。相比之下，线粒体 ETC 及其代谢产物在先天免疫细胞生物学中的作用，除了满足细胞 ATP 合成之外，直到最近才被人们所理解。在这里，我们讨论了我们对线粒体免疫功能的最新理解的最新进展，特别是线粒体呼吸链。
