Department of Fundamental Oncology, Faculty of Biology and Medicine, University of Lausanne, Epalinges, Vaud, Switzerland; Ludwig Lausanne Branch, Epalinges, Vaud, Switzerland.
Mitochondrion. 2018 Jul;41:45-50. doi: 10.1016/j.mito.2017.11.002. Epub 2017 Nov 14.
Orchestrating biological activities of immune cells through metabolic reprogramming reveals a new approach to harnessing immune responses. Increasing evidence reveals that the mitochondrion is a central regulator for modulating metabolic reprogramming and controlling immune cell activation and functions. In addition to supporting bioenergetic demands, the mitochondrion serves as a signaling platform through the generation of reactive oxygen species and metabolites of the tricarboxylic acid cycle to modulate signaling cascades controlling immune cell activation and immune responses. Herein, we discuss the mechanisms through which the mitochondrion acts as a master regulator to fine-tune immune responses elicited by macrophages and T cells.
通过代谢重编程来协调免疫细胞的生物活性揭示了一种利用免疫反应的新方法。越来越多的证据表明，线粒体是调节代谢重编程和控制免疫细胞激活和功能的中央调节剂。线粒体除了支持生物能量需求外，还通过生成活性氧和三羧酸循环的代谢物作为信号平台，调节控制免疫细胞激活和免疫反应的信号级联。本文讨论了线粒体作为主调控因子的作用机制，以微调巨噬细胞和 T 细胞引发的免疫反应。
