School of Life Sciences, University of Nottingham Medical School, Nottingham, NG7 2UH, UK.
School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, BS8 1TD, UK.
Br J Pharmacol. 2017 Dec;174 Suppl 1(Suppl Suppl 1):S360-S446. doi: 10.1111/bph.13883.
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.13883/full. Transporters are one of the eight major pharmacological targets into which the Guide is divided, with the others being: G protein-coupled receptors, ligand-gated ion channels, voltage-gated ion channels, other ion channels, nuclear hormone receptors, catalytic receptors and enzymes. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2017, and supersedes data presented in the 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature Committee of the Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.
《药理学概要 2017/18》提供了近 1800 个人类药物靶点的关键特性的简明概述,重点是选择性药理学(如适用),并链接到药物靶点及其配体的开放获取知识库(www.guidetopharmacology.org),其中提供了靶点和配体特性的更详细视图。尽管《药理学概要》约有 400 页,但与网站上呈现的信息和链接相比,呈现的材料大大减少。它提供了一个永久的、可引用的、时点记录,将在数据库更新后保留。本节的全部内容可在 http://onlinelibrary.wiley.com/doi/10.1111/bph.13883/full 找到。转运蛋白是该指南分为的八个主要药理学靶点之一,其他靶点包括:G 蛋白偶联受体、配体门控离子通道、电压门控离子通道、其他离子通道、核激素受体、催化受体和酶。这些都提供了命名指南和最佳可用药理学工具的摘要信息,以及关键参考文献和进一步阅读的建议。《药理学概要》的全景格式旨在促进对 2017 年中期相关靶点的比较,并取代了 2015/16 年和 2013/14 年《药理学概要》以及以前的《受体和通道指南》中呈现的数据。它是与基础和临床药理学联合会命名委员会(NC-IUPHAR)密切合作编写的,因此,在适当的情况下,为人类药物靶点提供了官方的 IUPHAR 分类和命名。