Molecular Neurobiology Laboratory, Department Biochemistry and Molecular Biomedicine, School of Biology, University of Barcelona, Diagonal 643, Catalonia, 08028, Barcelona, Spain.
Centro de Investigación en Red, Enfermedades Neurodegenerativas (CiberNed), Instituto de Salud Carlos iii, Madrid, Spain.
Cell Mol Life Sci. 2021 Apr;78(8):3957-3968. doi: 10.1007/s00018-021-03761-6. Epub 2021 Feb 12.
Adenosine is one of the most ancient signaling molecules and has receptors in both animals and plants. In mammals there are four specific receptors, A, A, A, and A, which belong to the superfamily of G-protein-coupled receptors (GPCRs). Evidence accumulated in the last 20 years indicates that GPCRs are often expressed as oligomeric complexes formed by a number of equal (homomers) or different (heteromers) receptors. This review presents the data showing the occurrence of heteromers formed by A and A, A and A, and A and A receptors highlighting (i) their tetrameric structural arrangements, and (ii) the functional diversity that those heteromers provide to adenosinergic signaling.
腺苷是最古老的信号分子之一，在动物和植物中都有受体。在哺乳动物中，有四种特定的受体，A、A、A 和 A，它们属于 G 蛋白偶联受体 (GPCR) 的超家族。过去 20 年积累的证据表明，GPCR 通常作为由多个相同 (同源物) 或不同 (异源物) 受体组成的寡聚体复合物表达。这篇综述介绍了表明由 A 和 A、A 和 A 以及 A 和 A 受体形成的异源二聚体存在的数据，突出了 (i) 它们的四聚体结构排列，以及 (ii) 这些异源二聚体为腺苷能信号提供的功能多样性。
