Clinical Health Science, Utrecht University, Utrecht, the Netherlands.
Department of Neonatology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht, the Netherlands.
Acta Paediatr. 2018 Feb;107(2):210-218. doi: 10.1111/apa.14124. Epub 2017 Nov 22.
This systematic review investigated the effectiveness of vaccinating healthcare workers against pertussis on the occurrence of nosocomial pertussis outbreaks or infections among unprotected infants. We focused on eight studies, with five different study designs, that involved 39,129 healthy adolescents and adults, 115 healthcare workers, 2000 simulated healthcare workers and a simulated population of 200,000 people.
There was moderate evidence that tetanus-diphtheria acellular pertussis vaccinations for healthcare workers were effective in preventing pertussis in all age groups and specifically in infants. The results must be interpreted with caution due to the low quality and heterogeneity of the studies.
本系统评价研究了为医护人员接种百日咳疫苗对未受保护的婴儿发生医院内百日咳暴发或感染的效果。我们重点关注了 8 项研究,这些研究采用了 5 种不同的研究设计,涉及 39129 名健康青少年和成年人、115 名医护人员、2000 名模拟医护人员和 20 万名模拟人群。
有中度证据表明,为医护人员接种无细胞百白破联合疫苗可有效预防所有年龄段人群的百日咳,特别是婴儿的百日咳。由于研究质量低且存在异质性,结果必须谨慎解释。