• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

系统评价发现，有中等证据表明为医护人员接种疫苗可预防婴儿百日咳。

Systematic review found that there was moderate evidence that vaccinating healthcare workers prevented pertussis in infants.

机构信息

Clinical Health Science, Utrecht University, Utrecht, the Netherlands.

Department of Neonatology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht, the Netherlands.

出版信息

Acta Paediatr. 2018 Feb;107(2):210-218. doi: 10.1111/apa.14124. Epub 2017 Nov 22.

DOI:10.1111/apa.14124
PMID:29055112
Abstract

UNLABELLED

This systematic review investigated the effectiveness of vaccinating healthcare workers against pertussis on the occurrence of nosocomial pertussis outbreaks or infections among unprotected infants. We focused on eight studies, with five different study designs, that involved 39,129 healthy adolescents and adults, 115 healthcare workers, 2000 simulated healthcare workers and a simulated population of 200,000 people.

CONCLUSION

There was moderate evidence that tetanus-diphtheria acellular pertussis vaccinations for healthcare workers were effective in preventing pertussis in all age groups and specifically in infants. The results must be interpreted with caution due to the low quality and heterogeneity of the studies.

摘要

本系统评价研究了为医护人员接种百日咳疫苗对未受保护的婴儿发生医院内百日咳暴发或感染的效果。我们重点关注了 8 项研究，这些研究采用了 5 种不同的研究设计，涉及 39129 名健康青少年和成年人、115 名医护人员、2000 名模拟医护人员和 20 万名模拟人群。

结论

有中度证据表明，为医护人员接种无细胞百白破联合疫苗可有效预防所有年龄段人群的百日咳，特别是婴儿的百日咳。由于研究质量低且存在异质性，结果必须谨慎解释。

相似文献

1
Systematic review found that there was moderate evidence that vaccinating healthcare workers prevented pertussis in infants.系统评价发现，有中等证据表明为医护人员接种疫苗可预防婴儿百日咳。
Acta Paediatr. 2018 Feb;107(2):210-218. doi: 10.1111/apa.14124. Epub 2017 Nov 22.
2
Assessment of safety and efficacy against Bordetella pertussis of a new tetanus-reduced dose diphtheria-acellular pertussis vaccine in a murine model.在小鼠模型中对一种新型低剂量破伤风白喉无细胞百日咳疫苗针对百日咳博德特氏菌的安全性和有效性评估。
BMC Infect Dis. 2017 Apr 4;17(1):247. doi: 10.1186/s12879-017-2369-x.
3
Assessing the reactogenicity of Tdap vaccine administered during pregnancy and antibodies to Bordetella pertussis antigens in maternal and cord sera of Thai women.评估在泰国孕妇孕期接种 Tdap 疫苗的反应原性和母血及脐血中百日咳鲍特菌抗原抗体。
Vaccine. 2018 Mar 7;36(11):1453-1459. doi: 10.1016/j.vaccine.2018.01.059.
4
Effectiveness of adolescent and adult tetanus, reduced-dose diphtheria, and acellular pertussis vaccine against pertussis.青少年和成人破伤风、白喉、无细胞百日咳疫苗对百日咳的有效性。
Clin Infect Dis. 2010 Aug 1;51(3):315-21. doi: 10.1086/653938.
5
Immunogenicity and safety of a second booster dose of an acellular pertussis vaccine combined with reduced antigen content diphtheria-tetanus toxoids 10 years after a first booster in adolescence: An open, phase III, non-randomized, multi-center study.青少年首针加强免疫 10 年后接种含低含量抗原白喉破伤风联合无细胞百日咳疫苗的二价加强免疫的免疫原性和安全性：一项开放、III 期、非随机、多中心研究。
Hum Vaccin Immunother. 2018;14(8):1977-1986. doi: 10.1080/21645515.2018.1460292. Epub 2018 May 10.
6
Acellular pertussis vaccine use in risk groups (adolescents, pregnant women, newborns and health care workers): a review of evidences and recommendations.无细胞百白破疫苗在风险人群（青少年、孕妇、新生儿和医护人员）中的使用：证据回顾与建议。
Vaccine. 2012 Jul 27;30(35):5179-90. doi: 10.1016/j.vaccine.2012.06.005. Epub 2012 Jun 15.
7
Antibody responses after primary immunization in infants born to women receiving a pertussis-containing vaccine during pregnancy: single arm observational study with a historical comparator.孕妇接种含百日咳疫苗后婴儿初次免疫后的抗体反应：与历史对照的单臂观察研究。
Clin Infect Dis. 2015 Dec 1;61(11):1637-44. doi: 10.1093/cid/civ695. Epub 2015 Sep 15.
8
Sustained efficacy during the first 6 years of life of 3-component acellular pertussis vaccines administered in infancy: the Italian experience.婴儿期接种的三组分无细胞百日咳疫苗在生命最初6年的持续效力：意大利的经验。
Pediatrics. 2001 Nov;108(5):E81. doi: 10.1542/peds.108.5.e81.
9
Tdap5 vaccine (Covaxis): a review of its use as a single-booster immunization for the prevention of tetanus, diphtheria, and pertussis in children (aged 4 years), adolescents, and adults.Tdap5 疫苗（Covaxis）：作为一种单剂疫苗，用于预防儿童（4 岁）、青少年和成人破伤风、白喉和百日咳的用途综述。
BioDrugs. 2010 Dec 1;24(6):387-406. doi: 10.2165/11206000-000000000-00000.
10
Reduced-antigen, combined diphtheria-tetanus-acellular pertussis vaccine, adsorbed (Boostrix) US formulation): use as a single-dose booster immunization in adolescents aged 10-18 years.吸附型低抗原白喉-破伤风-无细胞百日咳联合疫苗（百白破加强疫苗，美国配方）：用于10至18岁青少年的单剂量加强免疫。
Paediatr Drugs. 2006;8(3):189-95; discussion 196. doi: 10.2165/00148581-200608030-00005.

引用本文的文献

1
Vaccinating Front-Line Healthcare Workers: Results of a Pre-Pandemic Cross-Sectional Study from North-Eastern Italy on First Responders.为一线医护人员接种疫苗：意大利东北部一项关于急救人员的疫情前横断面研究结果
Vaccines (Basel). 2022 Sep 7;10(9):1492. doi: 10.3390/vaccines10091492.
2
Protocol of a scoping review assessing injury rates and their determinants among healthcare workers in western countries.评估西方国家医护人员伤害率及其决定因素的范围审查方案。
BMJ Open. 2019 Jan 30;9(1):e023372. doi: 10.1136/bmjopen-2018-023372.