Henien Marianne, Carey Barbara, Hullah Esther, Sproat Chris, Patel Vinod
Department of Oral Surgery, Guys Dental Hospital, London, UK.
Department of Oral Medicine, Guys Dental Hospital, London, UK.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2017 Dec;124(6):e283-e287. doi: 10.1016/j.oooo.2017.09.005. Epub 2017 Sep 21.
There has been a rise in medication-related osteonecrosis of the jaw (MRONJ) predominantly related to antiresorptive and antiangiogenic medications. More evidence is revealing that MRONJ is not limited to these drug groups. With the introduction of newer and varied medications used in the treatment of cancer and autoimmune diseases, reports of possible related osteonecrosis of the jaw (ONJ) are also on the rise. We present 2 cases of ONJ in patients with long-standing arthritis treated with methotrexate in the absence of a lymphoproliferative disorder and antiresorptive or antiangiogenic medications.
与药物相关的颌骨坏死（MRONJ）呈上升趋势，主要与抗吸收和抗血管生成药物有关。越来越多的证据表明，MRONJ并不局限于这些药物类别。随着用于治疗癌症和自身免疫性疾病的更新、更多样化药物的引入，颌骨坏死（ONJ）的可能相关报告也在增加。我们报告2例长期患有关节炎的患者在未患淋巴增生性疾病且未使用抗吸收或抗血管生成药物的情况下接受甲氨蝶呤治疗后发生ONJ的病例。
