尿液挥发性有机化合物分析快速诊断结核病。
Rapid Diagnosis of Tuberculosis from Analysis of Urine Volatile Organic Compounds.
机构信息
Metabolomx, Mountain View, California 94043, USA.
Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA.
出版信息
ACS Sens. 2016 Jul 22;1(7):852-856. doi: 10.1021/acssensors.6b00309. Epub 2016 Jun 9.
Abstract
The World Health Organization has called for simple, sensitive, and non-sputum diagnostics for tuberculosis. We report development of a urine tuberculosis test using a colorimetric sensor array (CSA). The sensor comprised of 73 different indicators captures high-dimensional, spatiotemporal signatures of volatile chemicals emitted by human urine samples. The sensor responses to 63 urine samples collected from 22 tuberculosis cases and 41 symptomatic controls were measured under five different urine test conditions. Basified testing condition yielded the best accuracy with 85.5% sensitivity and 79.5% specificity. The CSA urine assay offers desired features needed for tuberculosis diagnosis in endemic settings.
摘要
世界卫生组织呼吁开发简单、敏感、非痰检的结核病诊断方法。我们报告了一种使用比色传感器阵列（CSA）的尿液结核病检测方法的开发。该传感器由 73 种不同的指示剂组成，可捕获人类尿液样本中挥发性化学物质的高维、时空特征。在五种不同的尿液测试条件下，对来自 22 例结核病病例和 41 例有症状对照者的 63 份尿液样本进行了传感器响应测量。碱化测试条件的准确率最高，灵敏度为 85.5%，特异性为 79.5%。CSA 尿液检测方法具有在流行地区进行结核病诊断所需的理想特征。
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