Barnes J M, Barnes N M, Costall B, Naylor R J, Tattersall F D
Postgraduate School of Studies in Pharmacology, University of Bradford, U.K.
Neuropharmacology. 1988 Aug;27(8):783-90. doi: 10.1016/0028-3908(88)90092-5.
The involvement of 5-hydroxytryptamine (5-HT) with cisplatin-induced emesis in the ferret was investigated using reserpine, para-chlorophenylalanine and fenfluramine. Pretreatment with reserpine (5 mg/kg, 24 hr), fenfluramine (5 mg/kg, 4 days) or para-chlorophenylalanine (100 or 400 mg/kg, 4 days) antagonised cisplatin-induced emesis. All treatments reduced the levels of 5-HT in the area postrema and at other cerebral sites, but whilst this action was relatively selective for small doses of para-chlorophenylalanine [only modest effects on noradrenaline (NA) and no change in the content of dopamine (DA) in the area postrema], other treatments reduced levels of dopamine and noradrenaline. Data are discussed in terms of an involvement of 5-HT/catecholamines in the area postrema with the mediation of emesis induced by cisplatin.
利用利血平、对氯苯丙氨酸和芬氟拉明研究了5-羟色胺（5-HT）与雪貂顺铂诱导呕吐的关系。用利血平（5mg/kg，24小时）、芬氟拉明（5mg/kg，4天）或对氯苯丙氨酸（100或400mg/kg，4天）预处理可拮抗顺铂诱导的呕吐。所有处理均降低了最后区及其他脑区的5-HT水平，但小剂量对氯苯丙氨酸的这种作用具有相对选择性[仅对去甲肾上腺素（NA）有适度影响，且最后区多巴胺（DA）含量无变化]，而其他处理降低了多巴胺和去甲肾上腺素水平。根据最后区5-HT/儿茶酚胺参与顺铂诱导呕吐的介导作用对数据进行了讨论。
