Department of Physical Therapy, Faculty of Health Sciences, Recanati School for Community Health Professions, Ben-Gurion University of the Negev, P.O.B. 653, 84105, Beer Sheva, Israel.
Research Institute and Museum of Anthropology, Moscow State University, Moscow, Russia.
Rheumatol Int. 2018 May;38(5):865-870. doi: 10.1007/s00296-017-3831-1. Epub 2017 Oct 20.
To evaluate the association between the index and ring finger's (2D:4D) length ratio with the prevalence and severity of radiographic hand osteoarthritis (OA). A population-based sample included 802 males (mean age 46.98 ± 17.10 years) and 738 females (mean age 48.65 ± 16.62 years) who had participated in a Chuvashian skeletal aging study. Age, sex, basic demographics, anthropometric data and X-rays of both hands were acquired. Each hand was visually classified on X-ray as either type 1-index finger longer than the ring finger; type 2-index and ring finger equal in length; or type 3-index finger shorter than the ring finger. Hand OA was defined by the number of affected joints (Kellgren-Lawrence score ≥ 2) in both hands and the sum total of Kellgren-Lawrence scores (total OA score). After comparing the OA variables of individuals with different finger length ratio types (after adjustment for age and BMI) significant differences were found only in females between finger ratio types of the right hand in a number of affected joints (F = 3.153, p = 0.043) and finger ratio types of the left (F = 3.330, p = 0.036) and right (F = 2.397, p = 0.047) hands of the total OA score. Females with type 3 ratios had the highest adjusted values of hand OA parameters. We found that finger length ratios are associated with hand OA parameters. Females with a type 3 finger length pattern showed significantly higher hand OA values than those with types 1 and 2.
评估食指与无名指（2D：4D）长度比值与手部影像学骨关节炎（OA）患病率和严重程度的相关性。
采用基于人群的样本，纳入 802 名男性（平均年龄 46.98 ± 17.10 岁）和 738 名女性（平均年龄 48.65 ± 16.62 岁），所有参与者均参加了 Chuvashian 骨骼老化研究。获取年龄、性别、基本人口统计学、人体测量学数据和双手 X 线。对双手 X 线进行肉眼分类，分为 3 种类型：1 型-食指长于无名指；2 型-食指和无名指长度相等；3 型-食指短于无名指。双手影像学骨关节炎的定义为双侧受累关节数（Kellgren-Lawrence 评分≥2）和总 Kellgren-Lawrence 评分（总 OA 评分）。在调整年龄和 BMI 后，比较不同手指长度比值类型的 OA 变量，仅在女性中发现右手手指比值类型与受累关节数（F=3.153，p=0.043）和左手（F=3.330，p=0.036）、右手（F=2.397，p=0.047）的总 OA 评分存在显著差异。3 型比值的女性具有最高的手部 OA 参数调整值。
我们发现手指长度比值与手部 OA 参数相关。3 型手指长度模式的女性手部 OA 值明显高于 1 型和 2 型。
