Department of Internal Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Department of Pharmaceutical Services, Vanderbilt University Medical Center, Nashville, TN, USA.
Bone Marrow Transplant. 2018 Feb;53(2):123-128. doi: 10.1038/bmt.2017.222. Epub 2017 Oct 23.
Hematopoietic cell transplantation (HCT) offers definitive management for a wide variety of malignant and nonmalignant diseases. Conditioning regimens and therapies used to prevent and treat GvHD are immune suppressive, often increasing the risk of developing fungal disease due to yeasts or molds. Antifungal prophylaxis may be useful in preventing morbidity and mortality during and after HCT. In this article, we review the epidemiology and current literature regarding strategies for prevention of invasive fungal disease (IFD) in the pre-engraftment and post-engraftment settings, and propose future direction for scientific discovery.
造血细胞移植（HCT）为各种恶性和非恶性疾病提供了明确的治疗方法。用于预防和治疗移植物抗宿主病（GvHD）的调理方案和疗法具有免疫抑制作用，常因酵母或霉菌而增加发生真菌感染的风险。在 HCT 期间和之后，抗真菌预防可能有助于降低发病率和死亡率。本文综述了移植前和移植后侵袭性真菌病（IFD）预防策略的流行病学和现有文献，并为科学发现提出了未来的方向。
