Zhu Mei, Fu Weijun, Wang Zhiqiang, Xu Chen, Ji Baoming
College of Food and Drug, Luoyang Normal University, Luoyang, Henan 471022, P. R. China.
Org Biomol Chem. 2017 Nov 7;15(43):9057-9060. doi: 10.1039/c7ob02366a.
A photoredox-catalyzed direct difluoromethylation of alkynoates has been developed. A well-designed photoredox system induces a single-step, regioselective installation of CFH onto alkynes. Difluoromethyl sulfone was used as an easy to handle CFH radical source to afford the desired 3-difluoromethylated coumarins in moderate to good yields via a radical-triggered tandem difluoromethylation/5-exo cyclization/ester migration process.
已开发出一种光氧化还原催化的炔酸酯直接二氟甲基化反应。精心设计的光氧化还原体系可诱导将CFH一步、区域选择性地安装到炔烃上。二氟甲基砜用作易于处理的CFH自由基源，通过自由基引发的串联二氟甲基化/5-外环化/酯迁移过程，以中等至良好的产率得到所需的3-二氟甲基香豆素。
