Mi Xia, Wang Chenyang, Huang Mengmeng, Wu Yusheng, Wu Yangjie
†College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University, Zhengzhou 450052, P. R. China.
‡Tetranov Biopharm, LLC, 75 Daxue Road, Zhengzhou 450052, P.R. China.
J Org Chem. 2015 Jan 2;80(1):148-55. doi: 10.1021/jo502220b. Epub 2014 Dec 15.
A new and efficient metal-free tandem acylation/cyclization of alkynoates with aldehydes was developed for the synthesis of 3-acyl-4-arylcoumarins. The reaction was achieved by the addition of acyl radical to alkynes and a C-H bond functionalization to form two new C-C bonds simultaneously.
开发了一种用于合成3-酰基-4-芳基香豆素的新型高效炔酸酯与醛的无金属串联酰化/环化反应。该反应通过酰基自由基加成到炔烃上以及C-H键官能化同时形成两个新的C-C键来实现。
