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用于光热-化学联合治疗的近红外吸收染料功能化中空介孔二氧化硅纳米颗粒

NIR-absorbing dye functionalized hollow mesoporous silica nanoparticles for combined photothermal-chemotherapy.

作者信息

Zhang Yuanyuan, Qu Qiuyu, Cao Xiang, Zhao Yanli

机构信息

School of Chemical Engineering, Huaihai Institute of Technology, Lianyungang, 222005, P. R. China.

出版信息

Chem Commun (Camb). 2017 Nov 2;53(88):12032-12035. doi: 10.1039/c7cc07897h.

DOI:10.1039/c7cc07897h
PMID:29058740
Abstract

Multifunctional hollow mesoporous silica nanoparticles were constructed by firstly loading with doxorubicin and then capping with disulfide linked β-cyclodextrin followed by complexation with adamantane functionalized indocyanine dye, showing improved anticancer efficacy through combined photothermal-chemotherapy.

摘要

多功能中空介孔二氧化硅纳米粒子的构建方法是，先负载阿霉素，然后用二硫键连接的β-环糊精进行封端，接着与金刚烷功能化的吲哚菁染料络合，通过光热化疗联合显示出更高的抗癌疗效。

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