Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
J Cell Physiol. 2018 Jun;233(6):4512-4529. doi: 10.1002/jcp.26250. Epub 2018 Jan 15.
Innate lymphoid cells (ILCs) are kind of innate immune cells which can be divided into three main subsets according to their cytokine release profile, transcription factors, and surface markers. ILCs affect the initial stages of immunity in response to microbes and participate in immunity, inflammation, and tissue repair. ILCs modulate immunity through resistance to the pathogens and regulation of autoimmune inflammation and metabolic homeostasis. Therefore dysregulation of ILCs may lead to chronic pathologies such as allergies (i.e., asthma), inflammation (i.e., inflammatory bowel disease), and autoimmunity (i.e., psoriasis, atopic dermatitis, rheumatoid arthritis, multiple sclerosis, and ankylosing spondylitis). Regarding the critical role of ILCs in the regulation of immune system, the elucidation of their function in different conditions makes an interesting target for improvement of novel therapeutic approach to modulate an immune response in different disease context.
先天淋巴细胞（ILCs）是一种先天免疫细胞，根据其细胞因子释放谱、转录因子和表面标志物可分为三个主要亚群。ILCs 可影响对微生物的初始免疫反应，并参与免疫、炎症和组织修复。ILCs 通过抵抗病原体和调节自身免疫炎症及代谢稳态来调节免疫。因此，ILCs 的失调可能导致慢性病理，如过敏（即哮喘）、炎症（即炎症性肠病）和自身免疫（即银屑病、特应性皮炎、类风湿关节炎、多发性硬化症和强直性脊柱炎）。鉴于 ILCs 在免疫系统调节中的关键作用，阐明其在不同情况下的功能为改善新型治疗方法提供了一个有趣的目标，以调节不同疾病背景下的免疫反应。
