Department of Cardiovascular, Neural and Metabolic Sciences, S. Luca Hospital, IRCCS, Istituto Auxologico Italiano.
Department of Medicine and Surgery, University of Milano-Bicocca.
J Hypertens. 2018 Feb;36(2):344-352. doi: 10.1097/HJH.0000000000001571.
To determine plasma aldosterone concentration (PAC) and plasma renin concentration (PRC) and aldosterone-to-renin ratio (ARR) values in a population attending a Clinic for Cardiovascular Risk Assessment in Children.
We assessed ARR and associated factors in a cohort of 287 children (137 female, 4-18 years). Weight and blood pressure (BP) were recorded. PAC (ng/dl) and PRC (mU/l) were measured using direct immunochemiluminescent assays. Data were examined by sex and according to four age classes.
Median PAC was similar from the youngest to the oldest age class ranging from 7.5 to 9.9 ng/dl in males and from 11.0 to 12.6 ng/dl in females. Median PRC was also similar across age classes in males ranging from 58.2 to 55.5 mU/l, whereas it progressively decreased from 61.5 to 36.6 mU/l in females (P < 0.01). Median PRC was higher in prepubertal than in pubertal females only (53.6 vs. 40.2 mU/l, P < 0.03). As a result ARR was unchanged with increasing age in males (from 0.18 to 0.19), whereas in females it increased from 0.19 to 0.36 (P < 0.03). After adjusting for body weight, BP and other possible confounders, age was inversely related with PRC and directly with PAC and ARR (P < 0.001 for all), in females only. No relationship was found in both sexes between ARR values, BP, weight and family history of hypertension.
In our children population, ARR is lower than in adults and diverges with increasing age between sexes, due to the age and puberty driven fall in PRC observed only in females. BP and weight are not associated with ARR distribution.
确定在参加心血管风险评估诊所的人群中的血浆醛固酮浓度（PAC）和血浆肾素浓度（PRC）以及醛固酮与肾素比值（ARR）值。
我们评估了 287 名儿童（137 名女性，4-18 岁）的队列中的 ARR 和相关因素。记录体重和血压（BP）。使用直接免疫化学发光测定法测量 PAC（ng/dl）和 PRC（mU/l）。根据性别和四个年龄组检查数据。
从最小到最大年龄组，男性的中位数 PAC 相似，范围从 7.5 到 9.9ng/dl，女性的中位数 PAC 相似，范围从 11.0 到 12.6ng/dl。男性的中位数 PRC 也在各年龄组之间相似，范围从 58.2 到 55.5mU/l，而女性的 PRC 则逐渐从 61.5 降至 36.6mU/l（P<0.01）。在青春期前女性中，中位数 PRC 高于青春期女性（53.6 与 40.2mU/l，P<0.03）。因此，ARR 在男性中随着年龄的增加而保持不变（从 0.18 增加到 0.19），而在女性中则从 0.19 增加到 0.36（P<0.03）。在校正体重、BP 和其他可能的混杂因素后，仅在女性中，年龄与 PRC 呈负相关，与 PAC 和 ARR 呈正相关（P<0.001）。在两性中，ARR 值、BP、体重和高血压家族史之间均无关系。
在我们的儿童人群中，ARR 低于成年人，并且由于仅在女性中观察到 PRC 随年龄和青春期而下降，因此男女之间的 ARR 随着年龄的增长而不同。BP 和体重与 ARR 分布无关。
