Klebanov Nikolai, Reddy Bobby Y, Husain Sameera, Silvers David N, Grossman Marc E, Tsao Hensin
Department of Dermatology, Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Departments of Dermatology, and.
Am J Dermatopathol. 2018 May;40(5):378-382. doi: 10.1097/DAD.0000000000001023.
Malignant pleural mesothelioma is a rare neoplasm of mesodermal origin. Cutaneous involvement of malignant pleural mesothelioma is a very rare entity, with only 11 cases reported in the literature. Here, we describe the case of a 75-year-old man with stage IV epithelioid pleural mesothelioma, presenting with a cutaneous eruption 5 months after initial diagnosis, which revealed sarcomatoid features on skin biopsy. Histological analysis of malignancy progression through immunohistochemical staining of the pleural, lymph node, and skin tissue revealed gradual loss of calretinin and gain of desmin, supporting a transformation from epithelioid to sarcomatoid tissue. To our knowledge, this is the first reported case of an epithelioid to sarcomatoid transformation of malignant pleural mesothelioma manifesting in a cutaneous presentation.
恶性胸膜间皮瘤是一种罕见的中胚层起源的肿瘤。恶性胸膜间皮瘤累及皮肤是一种非常罕见的情况，文献中仅报道了11例。在此，我们描述了一例75岁男性，患有IV期上皮样胸膜间皮瘤，在初次诊断5个月后出现皮肤疹，皮肤活检显示具有肉瘤样特征。通过对胸膜、淋巴结和皮肤组织进行免疫组化染色对恶性进展进行组织学分析，发现钙视网膜蛋白逐渐丧失，结蛋白增加，支持从上皮样组织向肉瘤样组织的转变。据我们所知，这是首例报道的恶性胸膜间皮瘤从上皮样向肉瘤样转变并表现为皮肤症状的病例。
