Palmer E, Monaghan D T, Cotman C W
Department of Psychobiology, University of California, Irvine 92717.
Brain Res. 1988 Sep;464(2):161-5. doi: 10.1016/0169-328x(88)90008-3.
Excitatory amino acid receptors in the neonatal rat hippocampus have opposing actions on phosphoinositide (PI) metabolism. Quisqualic acid (QA), but not the QA receptor agonist AMPA (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid), potently stimulates inositol phosphate (IP) formation. Activation of NMDA (N-methyl-D-aspartate) receptors inhibits the QA-induced stimulation by 70% by a mechanism which is dependent on extracellular calcium.
新生大鼠海马体中的兴奋性氨基酸受体对磷酸肌醇（PI）代谢具有相反的作用。喹啉酸（QA）能有效刺激肌醇磷酸（IP）的形成，而QA受体激动剂α-氨基-3-羟基-5-甲基异恶唑-4-丙酸（AMPA）则不能。N-甲基-D-天冬氨酸（NMDA）受体的激活通过一种依赖细胞外钙的机制，使QA诱导的刺激作用抑制70%。
