疾病中RNA甲基化酶的突变。
Mutations in RNA methylating enzymes in disease.
作者信息
Stojković Vanja, Fujimori Danica Galonić
机构信息
Department of Cellular and Molecular Pharmacology, University of California San Francisco, 600 16th St, MC2280, San Francisco, CA 94158, United States.
Department of Cellular and Molecular Pharmacology, University of California San Francisco, 600 16th St, MC2280, San Francisco, CA 94158, United States; Department of Pharmaceutical Chemistry, University of California San Francisco, 600 16th St, MC2280, San Francisco, CA 94158, United States.
出版信息
Curr Opin Chem Biol. 2017 Dec;41:20-27. doi: 10.1016/j.cbpa.2017.10.002. Epub 2017 Oct 20.
RNA methylation is an abundant modification identified in various RNA species in both prokaryotic and eukaryotic organisms. However, the functional roles for the majority of these methylations remain largely unclear. In eukaryotes, many RNA methylations have been suggested to participate in fundamental cellular processes. Mutations in eukaryotic RNA methylating enzymes, and a consequent change in methylation, can lead to the development of diseases and disorders. In contrast, loss of RNA methylation in prokaryotes can be beneficial to microorganisms, especially under antibiotic pressure. Here we discuss several recent advances in understanding mutational landscape of both eukaryotic and prokaryotic RNA methylating enzymes and their relevance to disease and antibiotic resistance.
RNA甲基化是在原核生物和真核生物的各种RNA种类中发现的一种丰富的修饰。然而，这些甲基化中的大多数的功能作用在很大程度上仍不清楚。在真核生物中，许多RNA甲基化已被认为参与基本的细胞过程。真核生物RNA甲基化酶的突变以及随之而来的甲基化变化可导致疾病和紊乱的发生。相比之下，原核生物中RNA甲基化的缺失对微生物可能是有益的，尤其是在抗生素压力下。在这里，我们讨论了在理解真核生物和原核生物RNA甲基化酶的突变情况及其与疾病和抗生素抗性的相关性方面的几个最新进展。
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