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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Rohrer W H, Esch H, Saz H J

Department of Biological Sciences, University of Notre Dame, IN 46556.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1988;91(2):517-23. doi: 10.1016/0742-8413(88)90071-0.

A body wall preparation is described which permits intracellular recording from the somatic muscle cells of the small filarial nematode, Dipetalonema viteae. Using this preparation, resting membrane potentials were measured and spontaneous muscle depolarizations described. 2. Stimulatory effects noted upon the addition of acetylcholine, or the cholinergic agonists suggest the hypothesis that acetylcholine is the excitatory neurotransmitter. However, in contrast with vertebrate tissues, the cholinergic antagonists, d-tubocurarine, hexamethonium and pentolinium do not inhibit somatic muscle activity of the worm. 3. GABA inhibited somatic muscle depolarizations, suggesting the possibility that it may serve as an inhibitory neurotransmitter. 4. The anthelmintic drug, levamisole, produced a depolarizing block. Effects of other pharmacological agents are described, discussed and compared with effects on vertebrate muscles.

本文描述了一种体壁制备方法，该方法可对小型丝状线虫——马来布鲁线虫的体肌细胞进行细胞内记录。利用此制备方法，测量了静息膜电位并描述了自发性肌肉去极化。2. 添加乙酰胆碱或胆碱能激动剂时所观察到的刺激效应提示了乙酰胆碱是兴奋性神经递质这一假说。然而，与脊椎动物组织不同的是，胆碱能拮抗剂——d - 筒箭毒碱、六甲铵和喷托铵并不抑制该蠕虫的体肌活动。3. γ-氨基丁酸（GABA）抑制体肌去极化，提示其可能作为一种抑制性神经递质。4. 驱虫药左旋咪唑产生去极化阻滞。描述、讨论了其他药理剂的作用，并与它们对脊椎动物肌肉的作用进行了比较。

Rohrer W H, Esch H, Saz H J

Department of Biological Sciences, University of Notre Dame, IN 46556.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1988;91(2):517-23. doi: 10.1016/0742-8413(88)90071-0.

A body wall preparation is described which permits intracellular recording from the somatic muscle cells of the small filarial nematode, Dipetalonema viteae. Using this preparation, resting membrane potentials were measured and spontaneous muscle depolarizations described. 2. Stimulatory effects noted upon the addition of acetylcholine, or the cholinergic agonists suggest the hypothesis that acetylcholine is the excitatory neurotransmitter. However, in contrast with vertebrate tissues, the cholinergic antagonists, d-tubocurarine, hexamethonium and pentolinium do not inhibit somatic muscle activity of the worm. 3. GABA inhibited somatic muscle depolarizations, suggesting the possibility that it may serve as an inhibitory neurotransmitter. 4. The anthelmintic drug, levamisole, produced a depolarizing block. Effects of other pharmacological agents are described, discussed and compared with effects on vertebrate muscles.

本文描述了一种体壁制备方法，该方法可对小型丝状线虫——马来布鲁线虫的体肌细胞进行细胞内记录。利用此制备方法，测量了静息膜电位并描述了自发性肌肉去极化。2. 添加乙酰胆碱或胆碱能激动剂时所观察到的刺激效应提示了乙酰胆碱是兴奋性神经递质这一假说。然而，与脊椎动物组织不同的是，胆碱能拮抗剂——d - 筒箭毒碱、六甲铵和喷托铵并不抑制该蠕虫的体肌活动。3. γ-氨基丁酸（GABA）抑制体肌去极化，提示其可能作为一种抑制性神经递质。4. 驱虫药左旋咪唑产生去极化阻滞。描述、讨论了其他药理剂的作用，并与它们对脊椎动物肌肉的作用进行了比较。