Chiavarini M, Morini G, Barocelli E, Impicciatore M, Bordi F
Institute of Pharmacology and Pharmacognosy, University of Parma, Italy.
Farmaco Sci. 1988 May;43(5):479-87.
Two series of experiments were performed on rat chronic ulcer in order to assess the possible curative and mucosal protective properties of 2 week treatments, or the preventive properties of 4 week treatments with antisecretory agents, acting with different mechanisms of action. At the end of the treatments the gastric secretory and motor responsiveness to a gastrin-like stimulus was simultaneously evaluated. The results support the view that antimuscarinic agents as well as H2-blockers cannot be defined as protective and that after a 4 week treatment they can induce modifications of gastric functions.
为了评估作用机制不同的抗分泌药物进行2周治疗的可能疗效和黏膜保护特性，或4周治疗的预防特性，对大鼠慢性溃疡进行了两组实验。治疗结束时，同时评估胃对胃泌素样刺激的分泌和运动反应性。结果支持以下观点：抗毒蕈碱药物以及H2受体阻滞剂不能被定义为具有保护作用，并且在4周治疗后它们会引起胃功能的改变。
