Graf Jonathan
Division of Rheumatology, University of California, Zuckerberg San Francisco General Hospital, San Francisco, 1001 Potrero Avenue, Box 0811, San Francisco, CA 94110, USA.
Rheum Dis Clin North Am. 2017 Nov;43(4):547-560. doi: 10.1016/j.rdc.2017.06.004.
Neurologic manifestations are common in patients with antiphospholipid antibodies and include stroke, seizures, dementia, cognitive dysfunction, chorea, migraine, psychosis, and demyelinating disease. Many of these disorders mimic their idiopathic counterparts, yet treatment for antiphospholipid antibody-associated disease can be quite different compared with treatment of CNS disease not associated with these antibodies. For patients with antiphospholipid antibody-associated neurologic disease, anticoagulation or immunosuppressive therapy or both may significantly improve their symptoms. Thus, one should have a high index of suspicion for antiphospholipid syndrome in the appropriate clinical context.
抗磷脂抗体患者常出现神经系统表现，包括中风、癫痫、痴呆、认知功能障碍、舞蹈症、偏头痛、精神病和脱髓鞘疾病。这些疾病中的许多与特发性疾病相似，但与抗磷脂抗体相关疾病的治疗与不伴有这些抗体的中枢神经系统疾病的治疗可能有很大不同。对于抗磷脂抗体相关神经系统疾病患者，抗凝治疗或免疫抑制治疗或两者联合使用可能会显著改善其症状。因此，在适当的临床背景下，应高度怀疑抗磷脂综合征。
