用蛙皮素治疗迟发性运动障碍。

Treatment of tardive dyskinesia with ceruletide.

Nishikawa T, Tanaka M, Tsuda A, Koga I, Uchida Y

Department of Pharmacology, Kurume University School of Medicine, Japan.

Prog Neuropsychopharmacol Biol Psychiatry. 1988;12(5):803-12. doi: 10.1016/0278-5846(88)90025-5.

Abstract

Seven patients with TD were treated with a single dose of ceruletide 0.8 microgram/kg i.m. 2. EMG and MV were recorded, and the average power spectrum was computed. 3. Effect of ceruletide on TD within 2 hr after injection was varied (3 cases: inhibitory, 2 cases: facilitatory, 2 cases: no effect). 4. Two patients with severe TD, who showed improvement after a single administration, received repeated administration of ceruletide (0.6 microgram/kg i.m.) and their TD symptoms were recorded on videotape for blind consensus ratings. In both patients ceruletide caused a marked decrease in severity of TD, and the effects lasted for several weeks. 5. The present findings might contribute to further understanding of the role of CCK in the brain and to the treatment of TD.

摘要

7例迟发性运动障碍（TD）患者接受了单次肌内注射0.8微克/千克雨蛙肽的治疗。
记录了肌电图（EMG）和运动速度（MV），并计算了平均功率谱。
注射后2小时内，雨蛙肽对TD的影响各不相同（3例：抑制，2例：促进，2例：无影响）。
2例重度TD患者单次给药后症状改善，接受了雨蛙肽重复给药（0.6微克/千克肌内注射），其TD症状被录像以进行盲法一致性评分。在这2例患者中，雨蛙肽均使TD严重程度显著降低，且效果持续数周。
本研究结果可能有助于进一步理解胆囊收缩素（CCK）在大脑中的作用以及TD的治疗。