Nishikawa T, Tanaka M, Tsuda A, Kuwahara H, Koga I, Uchida Y
Psychopharmacology (Berl). 1986;90(1):5-8. doi: 10.1007/BF00172862.
Seven patients with bucco-lingual dyskinesia were treated with a single dose of ceruletide 0.8 micrograms/kg IM, a potent analogue of cholecystokinin octapeptide. Time-course effects of the drug were then followed up to 6 weeks after injection in the longest case. To assess changes in severity of dyskinesia objectively, electromyogram and microvibration were recorded. These data were subjected to the Fast Fourier Transform and an averaged power spectrum was computed. The effect of ceruletide on dyskinesia within 2 h after injection differed (three cases: inhibitory, two cases: facilitatory, two cases: no effect). It was notable that a long-lasting inhibitory effect of this peptide was observed in two severe irreversible cases. The present findings might contribute to further understanding of the physiopathophysiological role of cholecystokinin-like peptides in the brain and to practical treatment of tardive dyskinesia.
7例患有颊舌运动障碍的患者接受了单次剂量为0.8微克/千克的蛙皮素肌肉注射治疗，蛙皮素是一种有效的八肽胆囊收缩素类似物。然后对最长病例注射后长达6周的药物时程效应进行随访。为了客观评估运动障碍严重程度的变化，记录了肌电图和微振动情况。对这些数据进行快速傅里叶变换并计算平均功率谱。注射后2小时内，蛙皮素对运动障碍的影响有所不同（3例：抑制作用，2例：促进作用，2例：无作用）。值得注意的是，在2例严重不可逆病例中观察到了该肽的持久抑制作用。目前的研究结果可能有助于进一步了解脑内胆囊收缩素样肽的生理病理生理作用以及迟发性运动障碍的实际治疗。
