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重新审视再循环蛋白：再循环蛋白在内涵体分选中的作用不断演变。

Retromer revisited: Evolving roles for retromer in endosomal sorting.

机构信息

Department of Biochemistry, Boston University School of Medicine, Boston, MA.

Department of Biochemistry, Boston University School of Medicine, Boston, MA

出版信息

J Cell Biol. 2017 Nov 6;216(11):3433-3436. doi: 10.1083/jcb.201708111. Epub 2017 Oct 23.

DOI:10.1083/jcb.201708111
PMID:29061649
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5674901/
Abstract

The highly conserved retromer complex has been linked to cargo retrieval from endosomes to the trans-Golgi network. In this issue, Kvainickas et al. (2017. https://doi.org/10.1083/jcb.201702137) and Simonetti et al. (2017. https://doi.org/10.1083/jcb.201703015) fundamentally question the current retromer model and demonstrate that in mammalian cells, the individual retromer subcomplexes have functionally diverged to organize multiple distinct sorting pathways.

摘要

高度保守的逆行转运复合体(retromer complex)与从内体(endosomes)向反式高尔基网络(trans-Golgi network)回收货物有关。在本期中，Kvainickas 等人（2017. https://doi.org/10.1083/jcb.201702137）和 Simonetti 等人（2017. https://doi.org/10.1083/jcb.201703015）从根本上质疑了当前的逆行转运模型，并表明在哺乳动物细胞中，单个逆行转运亚复合物在功能上已经分化，以组织多种不同的分选途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a81/5674901/727a804f5726/JCB_201708111_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a81/5674901/727a804f5726/JCB_201708111_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a81/5674901/727a804f5726/JCB_201708111_Fig1.jpg

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