一种新的 NLRP3 抑制靶点。
A new lead to NLRP3 inhibition.
机构信息
VIB-UGent Center for Inflammation Research, VIB; and Department of Internal Medicine, Ghent University, Ghent, Belgium; Department of Physiological Chemistry, Genentech, South San Francisco, CA.
VIB-UGent Center for Inflammation Research, VIB; and Department of Internal Medicine, Ghent University, Ghent, Belgium; Department of Physiological Chemistry, Genentech, South San Francisco, CA
出版信息
J Exp Med. 2017 Nov 6;214(11):3147-3149. doi: 10.1084/jem.20171848. Epub 2017 Oct 23.
The discovery of a small molecule inhibitor that targets the inflammasome sensor NLRP3 offers a new path for the development of selective inflammasome blockers with potential therapeutic benefit in a wide range of human diseases (in this issue, see Jiang et al., https://doi.org/10.1084/jem.20171419).
小分子抑制剂靶向炎症小体传感器 NLRP3 的发现为开发选择性炎症小体抑制剂提供了新途径，这种抑制剂可能在广泛的人类疾病中具有治疗益处（本期文章请参见 Jiang 等人，https://doi.org/10.1084/jem.20171419）。
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