Klug H, Schulze P
Department of Dermatology, Charité, Humboldt-University, Berlin, German Democratic Republic.
Virchows Arch B Cell Pathol Incl Mol Pathol. 1988;56(3):201-3. doi: 10.1007/BF02890018.
Electron microscopic investigation of skin biopsies revealed that keratinocytes in clinically uninvolved skin from psoriatic patients show the same mitochondrial ring phenomenon after the application of dithranol as has been observed in the cutaneous lesions proper. In various other skin diseases no mitochondrial reaction was evident after dithranol treatment, nor was it seen in chronic dermatitis when dithranol was not applied. It appears, therefore, that this morphological phenomenon is specific to psoriasis and may provide information concerning functional alterations in the pathogenesis of this disease.
对皮肤活检组织的电子显微镜检查显示，银屑病患者临床未受累皮肤中的角质形成细胞在应用蒽林后，出现了与在银屑病皮损中所观察到的相同的线粒体环状现象。在其他各种皮肤病中，蒽林治疗后未出现明显的线粒体反应，未应用蒽林时在慢性皮炎中也未观察到该现象。因此，这种形态学现象似乎是银屑病所特有的，并且可能为该疾病发病机制中的功能改变提供信息。
