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[多种神经介质活性在支持大脑整合功能中的意义]

[The significance of multiple neuromediator activity in supporting integrative brain functions].

作者信息

Kotliar B I, Miasnikov A A

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1988 Sep-Oct;38(5):931-8.

PMID:2906195
Abstract

Properties were studied of reactions of neural cells of the sensorimotor cortical area to locally microionophoretically administered l-glutamate, acetylcholine, norepinephrine and gamma-aminobutyric acid. It is shown that neuronal reactions to the action of the above-mentioned transmitters differ both in direction of change in the impulse activity frequency and in temporal offracteristics (latency and duration of after-effect). It is substantiated that due to the specificity of temporal ranges of action of the transmitter on neural cells, the possibility of effective interaction and temporal coding of heterofunctional information is provided.

摘要

研究了感觉运动皮层区域神经细胞对局部微量离子电泳给予的L-谷氨酸、乙酰胆碱、去甲肾上腺素和γ-氨基丁酸反应的特性。结果表明,神经元对上述递质作用的反应在冲动活动频率变化方向和时间特征(潜伏期和后效应持续时间)上均有所不同。证实了由于递质对神经细胞作用的时间范围具有特异性,从而提供了异功能信息有效相互作用和时间编码的可能性。

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