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[微离子电泳法研究各种神经递质对延髓呼吸中枢神经元活动的影响]

[Microionophoretic study of the effect of various neurotransmitters on the activity of neurons in the bulbar respiratory center].

作者信息

Baklavadzhian O G, Nersesian L B, Oleĭnik G N, Sarukhanian R V

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1982 Dec;68(12):1631-8.

PMID:6131844
Abstract

Three putative neurotransmitters (L--glutamate--L--GL; GABA and noradrenaline--NA) were applied to bulbar respiratory neurons and for comparison, to unspecific cells. L--GL induced excitation in all tested inspiratory, expiratory and unspecific neurons of the bulbar respiratory area. GABA depressed the firing of respiratory and unspecific neurons. Stimulation of NA receptors resulted in neuronal activation or inhibition with prevailing excitatory effects for all three types of the neurons. Two types of NA-specific receptors seem to exist among the respiratory and nonrespiratory neurons of the bulbar region of dorsal and ventral respiratory areas.

摘要

将三种假定的神经递质(L -谷氨酸 - L - GL;γ-氨基丁酸 - GABA和去甲肾上腺素 - NA)作用于延髓呼吸神经元,作为对照,也作用于非特异性细胞。L - GL可使延髓呼吸区所有受试的吸气、呼气和非特异性神经元兴奋。GABA可抑制呼吸和非特异性神经元的放电。刺激NA受体可导致所有三种类型神经元的激活或抑制,且主要表现为兴奋作用。在背侧和腹侧呼吸区延髓区域的呼吸和非呼吸神经元中似乎存在两种类型的NA特异性受体。

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