Leone M, Costa M, Capitanio G L, Palmero S, Prati M, Leone M M
Istituto di Clinica Ostetrica e Ginecologica, Università di Genova, Italy.
Acta Eur Fertil. 1988 Mar-Apr;19(2):99-103.
In order to evaluate the effect of dipromochloropropane (DBCP) on reproductive function, groups of male adult Wistar rats were injected subcutaneously with different doses of DBCP. A strictly dose-dependent effect resulting in histological alteration principally toward the seminiferous tubules was observed. Sperm count and sperm motility showed azoospermia or oligoasthenospermia with a significative recovery in the lower dose of DBCP treated rats. Among the enzymatic activities evaluated as biochemical markers of testicular function: LDH was not appreciably affected by the DBCP treatment while GGT and NADPH-cyt P450-reductase significantly enhanced suggesting an induction of the detoxification processes.
为了评估二溴氯丙烷（DBCP）对生殖功能的影响，将成年雄性Wistar大鼠分组，皮下注射不同剂量的DBCP。观察到一种严格的剂量依赖性效应，主要导致生精小管的组织学改变。精子计数和精子活力显示无精子症或少弱精子症，在低剂量DBCP处理的大鼠中有显著恢复。在作为睾丸功能生化标志物评估的酶活性中：乳酸脱氢酶（LDH）未受到DBCP处理的明显影响，而γ-谷氨酰转移酶（GGT）和NADPH-细胞色素P450还原酶显著增强，表明解毒过程被诱导。
