Bantutova I, Ovcharov R, Koburova K
Acta Physiol Pharmacol Bulg. 1978;4(2):26-9.
In experiments on 72 male Wistar rats, chronically treated with phenobarbital and diazepam, studies are made of the change in the convulsion threshold after sound stimulation during treatment and after withdrawal of the drugs. The level of biogenic amines in the brain at the end of the treatment (60th day) and after withdrawal of the drugs (3rd day) was also determined. The convulsion threshold was found to be considerably lower on the 3rd day after drug withdrawal in rats treated with phenobarbital and to a lesser extent (also on the 3rd day) in rats treated with diazepam. Serotonin level is considerably lower in both groups of animals. The significance of the disturbed correlation between serotonin and noradrenaline and particularly the sharp decrease of the serotonin level for the appearance of intensified convulsion activity is discussed.
在对72只雄性Wistar大鼠进行的实验中，长期用苯巴比妥和地西泮进行处理，研究了在处理期间及停药后声音刺激后惊厥阈值的变化。还测定了处理结束时（第60天）及停药后（第3天）大脑中生物胺的水平。发现用苯巴比妥处理的大鼠在停药后第3天惊厥阈值显著降低，用地西泮处理的大鼠在较小程度上（同样在第3天）惊厥阈值也降低。两组动物的血清素水平均显著降低。讨论了血清素与去甲肾上腺素之间相关性紊乱的意义，特别是血清素水平急剧下降对惊厥活动增强出现的影响。
